Reference Number: JO-2403-532004
DMPK Group Leader
Rate: £74,000 – 76,000
Job Type: Permanent
Location: Cambridge

DMPK Group Leader

Up to £76,000 depending on experience



Cpl Life Sciences have partnered with a leading and highly regarded charity organization in the UK to recruit for a DMPK Group Leader.

Key Responsibilities:

• Design, propose and execute innovative experiments which positively impact projects and the overall direction of in vitro/in vivo science.

• Maintain awareness of external developments in the DMPK and PKPD fields, the application of these to on-going projects and proactively suggest and evaluate new techniques.

• Contribute to the strategic leadership within the Medicinal Chemistry and DMPK group, as well as the overall Therapeutic Innovation research strategy.

• Effectively manage appropriate outsourcing activities.

• Effectively prioritise and co-ordinates multiple areas of work.

• Lead and drive a high-performing team to provide all aspects of DMPK and PKPD expertise. 

• Manage internal expertise, capacity, and resources to drive governance and decision-making regarding scientific portfolio support and technology development.

• Present and clarify results across departments and to alliance partners.

• Be a recognised and passionate leader, able to represent the department across a broad range of therapeutic projects and cross-site initiatives, both internally as well as externally.

• Drive scientific and technical innovation, including through external collaboration and partnership. 

Skills required:

• PhD or equivalent experience in Pharmaceutics, Pharmacology, Drug metabolism or Pharmacokinetics encompassing a significant element of Modelling & Simulation, such as quantitative pharmacology, systems biology, pharmacometrics, applied mathematics.

• Significant experience and deep expertise in DMPK aspects of drug discovery.

• Relevant industry experience in Modelling & Simulation in a preclinical and translational setting.

• Proven track record of delivering PK, PKPD and TKPD aspects to projects, including significant experience in translating drug-target kinetics through to mechanistic PKPD modelling for therapeutic dose prediction.

• Expert in specialist tools such as MATLAB, SimCYP, WinNonLin/Phoenix NLME.

• Proven track record of portfolio impact across a range of challenging target classes, through intellectual and laboratory-based contributions, and project leadership.

• Strong external reputation in translational PKPD modelling and DMPK, evidenced through wide personal network, external presentation, and publication in high-impact journals.

• Track record of delivering results across a diverse project portfolio by driving strategic and scientific initiatives.

• Deep expertise in translational PKPD modelling and DMPK. 

• Confidence and credibility to work at the intersection between mechanistic pharmacology, medicinal chemistry, computational chemistry & DMPK to define and prosecute strategies that deliver impactful insight across a range of challenging target classes, through to clinical dose prediction.

• Excellent communication skills, ability to influence multiple stakeholders and collaborate across projects and sites.

• A passion for promotion of scientific excellence, through external publication, presentations etc.

• Excellent team-working skills combined with cross-functional knowledge

If you are interested in this fantastic and unique opportunity, please send your CV to daniel.bailey@cpl.com

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