Reference Number: JO-2403-532032
Senior Principle Scientist – Enzymology
Rate: Negotiable
Job Type: Permanent
Location: Cambridge

Senior Principle Scientist – Enzymology

Permanent, Full time (35 Hours)

Up to £76,000 per annum


Cpl Life Sciences have partnered with a leading and highly regarded charity organization in the UK to recruit for a Senior Principle Scientist within Enzymology. As the Senior Principal Scientist (SPS) Enzymology, you will be an inspirational scientist with an exceptional record of bringing your deep knowledge of enzymology and drug-target kinetics to impact on projects.

We are seeking an accomplished scientific leader who can articulate a vision for our mission and set direction and inspire commitment for preclinical Drug Discovery.

What will I be doing?

• Provide deep expertise in mechanistic enzymology and its role in drug discovery.

• Provide scientific and strategic leadership for the Molecular Sciences department, and wider group, to drive innovation and portfolio success.

• Work at the intersection between mechanistic biology, medicinal chemistry, computational chemistry, structural biology & DMPK to define and prosecute strategies that deliver mechanistic insight across a range of challenging target classes, from initial target characterisation through to clinical dose prediction.

• Communicate effectively, to influence multiple stakeholders and collaborate across projects and sites, and externally.

• Promote scientific excellence, through external publication, presentations, and membership of conference committees and Scientific Advisory Boards.

• Play a pivotal role in training and developing colleagues, including through practical contributions from the bench.

What skills and experience are we looking for?

• PhD in Enzymology, Pharmacology, or equivalent experience.

• Significant experience and deep expertise in mechanistic enzymology in a drug discovery environment.

• Proven track record of innovative scientific delivery through driving impactful mechanistic enzymology insight in drug discovery programmes, including detailed characterisation of multi-substrate enzyme mechanisms and drug mechanism-of-action.

• Significant experience in translating drug-target kinetics through to mechanistic PKPD modelling for therapeutic dose prediction.

• Proven track record of portfolio impact across a range of challenging target classes, through intellectual and laboratory-based contributions, and project leadership.

• Strong external reputation in mechanistic enzymology and drug discovery, evidenced through wide personal network, external presentation and publication in high-impact journals, and influential roles on relevant external committees.

• Significant experience in inspiring and developing a diverse world-class group, whilst working in a highly matrixed discovery project environment

• Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects.

If this role is of interest to you, please reach out to me at daniel.bailey@cpl.com

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