Researchers at the SUNY Upstate Medical University have found that a key cellular enzyme, c-Abl, could be an effective drug target in cancer cells for urologic cancers, such as prostate and kidney. Currently kidney cancer is known to be resistant against chemotherapy and radiation. About 61,000 new cases of kidney cancer are diagnosed each year,
International Clinical Trials day takes place on the 20th May each year to honour the day James Lind began the first clinical trials with control groups. The trial involved 12 people who were given different dietary supplements to see the effect of their diets on scurvy. Clinical trials are used to test new drugs and
Pfizer have announced positive Phase III clinical trial results for their JAK inhibitor, Xeljanz (tofacitinib). The results from data taken from two Phase III clinical trials provide additional support for the drug’s use to treat moderate to severe psoriasis. Pfizer commented that the results from the trials show that both tofacitinib 10mg and 5mg tablets
Biogen Idec has announced plans to move their investigational Alzheimer’s drug into Phase III trials, after receiving promising early-stage clinical data. Douglas Williams, Biogen Idec’s R&D chief, noted that in the interim analysis of their Phase Ib clinical trial, aducanumab (also known as BIIB037) showed a significant reduction in the beta-amyloid protein in early-stage patients.
Bayer HealthCare has confirmed that they have begun a Phase II clinical trial of riociguat for the treatment of diffuse cutaneous systemic sclerosis (dcSSc). Systemic sclerosis is a rare multisystem, autoimmune disease that results in the overproduction and abnormal growth of collagen, which causes fibrosis of the skin and internal organs. dcSSc is one of
GlaxoSmithKline (GSK) have confirmed that they are trying to compress the clinical trials of their potential Ebola vaccine into just 12 months. Normally it could take up to ten years to run clinical trials, with it typically taking 6 to 11 months to move an experimental vaccine from preclinical testing into clinical trials. However, due
A major change to UK patent law which took effect yesterday could help attract more clinical studies to the UK. The amendment to the patent law allows organisations to use a patented product when carrying out clinical trials, removing the risk of infringement claims. The amendment is an addition to the existing ‘Bolar Exemption’, a
UCB has today announced positive topline clinical results for epilepsy drug, brivaracetam, from their most recent Phase III clinical study. The aim of clinical trial was to assess the effectiveness of brivaracetam as adjunctive treatment in adults not fully controlled despite treatment with one or two concomitant antiepileptic drugs, in comparison to placebo. Results of
The Medical Research Council (MRC) has announced the launch of the world’s largest study into dementia, involving more than two million people. The clinical study will be conducted through the Medical Research Council and industry partners. The UK Dementias Research Platform (UKDP) will investigate the causes of dementia across a range of different neurodegenerative conditions,
Results from three late-stage clinical trials have demonstrated that Eli Lilly’s diabetes drug, Peglispro, is more effective at reducing blood sugar in patients with type II diabetes than Sanofi’s Lantus. Yesterday, Eli Lilly confirmed that they are expecting to file for regulatory approval by the first quarter of 2015, after the Phase III clinical studies
